Self-assembling of amphiphilic drug amitriptyline hydrochloride in the presence of additives: Role of surface activity in the pharmaceutical applications

The self-assembling of surface active antidepressant drug amitriptyline hydrochloride (AMT) has been studied to determine the micellar solution behavior in presence polar (methanol and ethanol), dipolar aprotic solvents (acetone 1,4 dioxane), salt (NaCl) water structure-breakers (urea) at 298 K using tension electrical conductivity measurements. counterion binding parameter ionization degree AMT micelles have determined by To better analyze influences additives on AMT, features were defined Gibbs Adsorption Isotherm association with various amounts conducted Both conductometric experiments also used detect critical micelle concentration (CMC) AMT. experimental results indicated that CMCs influenced additives. Self-aggregation was totally inhibited when methanol, ethanol, acetone, dioxane, urea is attained a certain value while CMC reduced increase NaCl.